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Richard Lin

M.D., University of California, San Francisco, 1988
Biology of Phosphoinositide 3-Kinases

Basic Science Tower, T-6, Room 180
Stony Brook University
Stony Brook, NY, 11794-8661

Phone: (631) 444-1638
Email: Richard.Lin@sunysb.edu



Biology of Phosphoinositide 3-Kinases

The research effort focuses on understanding the physiological functions and pathological roles of phosphoinositide 3-kinases (PI3Ks). These lipid kinases produce the intracellular second messenger phosphatidylinositol 3,4,5-trisphosphate that regulates diverse biological functions, including insulin action, neutrophil chemotaxis, and cell growth, proliferation and death. One major emphasis in this laboratory is to elucidate how individual PI3K catalytic isoforms regulate the contractile function and electrical properties of cardiac myocytes. Another major focus of the laboratory is to investigate how PI3Ks are involved in the development of pancreatic cancer. Other projects concern how PI3Ks control cellular and organismal metabolism.

Selected Publications

2012 Lu Z., Wu C.-Y. C., Jiang Y.-P., Ballou L. M., Clausen C., Cohen I. S., and Lin R.Z., Suppression of phosphoinositide 3-kinase signaling and alteration of multiple ion currents in drug-induced long QT syndrome. Sci. Transl. Med. 4, 131ra50
2012 Jaber N., Dou Z., Chen J.S., Catanzaro J., Jiang Y.-P., Ballou L.M., Selinger E., Ouyang X., Lin R.Z., Zhang J., and Zong W.X. The Class III PI3K Vps34 plays an essential role in autophagy and in the heart and liver function. PNAS 109(6):2003-2008
2011 Wu C.-Y., Jia Z., Wang W., Ballou L.M., Jiang Y.-P., Chen B., Mathias R.T., Cohen I.S., Song L.-S., Entcheva E., Lin R.Z. PI3Ks maintain the structural integrity of T-tubules in cardiac myocytes. PLoS One 6(9):e24404
2011 Lu Z., Ballou L.M., Jiang Y.-P., Cohen I.S. and Lin R.Z. Restoration of defective L-type Ca2+ current in cardiac myocytes of type 2 diabetic db/db mice by Akt and PKCiota. J. Cardiovasc. Pharmacol. 58(4):439-445
2011 Chattopadhyay M., Selinger E.S., Ballou L.M. and Lin R.Z. Ablation of PI3K p110α prevents high-fat diet-induced liver steatosis. Diabetes 60(5):1483-1492
2010 Dou Z., Chattopadhyay M., Pan J.A., Guerriero J.L., Jiang Y.-P., Ballou L.M., Yue Z., Lin R.Z. and Zong W.X. The Class IA phosphatidylinositol 3-kinase p110β subunit is a positive regulator of autophagy. J. Cell Biol. 191(4):827-843
2009 Lu Z., Jiang Y.-P., Wang W., Xu X.-H., Mathias R.T., Entcheva E., Ballou L.M., Cohen I.S. and Lin R.Z. Loss of cardiac phosphoinositide 3-kinase p110α results in contractile dysfunction. Circulation  120(4):318-325
2007 Lu Z., Jiang Y.-P., Xu X.-H., Ballou L.M., Cohen I.S. and Lin R.Z. Decreased L-type Ca2+ current in cardiac myocytes of type 1 diabetic Akita mice due to reduced phosphatidylinositol 3-kinase signaling. Diabetes 56:2780-2789
2007 Ballou L.M., Selinger E.S., Choi J.Y., Drueckhammer D.G. and Lin R.Z. Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)pyrimido[2,1-α] isoquinolin-4-one. J. Biol. Chem. 282:24463-24470
2006 Jiang Y.-P., Ballou L.M., Lu Z., Wan L., Kelly D.J., Cohen I.S. and Lin R.Z. Reversible heart failure in Gαq transgenic mice. J. Biol. Chem. 281:29988-29992
2006 Ballou L.M., Chattopadhyay M, Li Y., Scarlata S. and Lin R.Z. Gαq binds to p110α/p85α phosphatidylinositol 3-kinase and displaces Ras. Biochem. J. 394:557-562
2005 Lu Z., Jiang Y.-P., Ballou L.M., Cohen I.S. and Lin R.Z. Gαq inhibits cardiac L-type Ca2+ channels through phosphatidylinositol 3-kinase. J. Biol. Chem. 280:40347-40354
2005 Fan G., Jiang Y.-P., Lu Z., Martin D.W., Kelly D.J., Zuckerman J.M., Ballou L.M., Cohen I.S. and Lin R.Z. A transgenic model of heart failure using inducible Gαq. J. Biol. Chem. 280:40337-40346
2003 Ballou L.M., Jiang Y.-P., Du G., Frohman M.A. and Lin R.Z. Ca2+- and phospholipase D-dependent and -independent pathways activate mTOR signaling. FEBS Lett. 550:51-56
2003 Ballou L.M., Tian P., Lin H.-Y., Fan G., Jiang Y.-P., Rybkin I.I., and Lin R.Z. Activated Gαq inhibits p110α phosphatidylinositol 3-kinase and Akt. J. Biol. Chem. 278:23472-23479
2001 Ballou L.M., Tian P.-Y., Lin H.-Y., Jiang Y.-P. and Lin R.Z. Dual regulation of glycogen synthase kinase-3β by the α1A adrenergic receptor. J. Biol. Chem. 276:40910-40916
2001 Jiang Y.-P., Ballou L.M. and Lin R.Z.  Rapamycin-insensitive regulation of 4E-BP1 in regenerating rat liver. J. Biol. Chem. 276:10943–10951



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