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Richard Lin
Professor

M.D., University of California, San Francisco, 1988
Biology of Phosphoinositide 3-Kinases

Basic Science Tower, T-6, Room 180
Stony Brook University
Stony Brook, NY, 11794-8661

Phone: (631) 444-1638
Email: Richard.Lin@sunysb.edu

   

Research

Biology of Phosphoinositide 3-Kinases

Our research focuses on understanding the physiological functions and pathological roles of phosphoinositide 3-kinases(PI3Ks). This family of lipid kinases produces the intracellular second messenger phosphatidylinositol 3,4,5-trisphosphate that regulates insulin action, cell proliferation and death, neutrophil and lymphocyte function, ion channel currents, and many other diverse biological functions. One research area our laboratory is currently investigating concerns the role of PI3K in pancreatic cancer. Abnormal upregulation of PI3K signaling is one of the most common oncogenic contributors in the development of human cancers. We discovered that the p110α isoform of PI3K is essential for the initiation of pancreatic cancer caused by oncogenic Kras. We are now investigating the role of p110α in the maintenance and progression of pancreatic cancer. A second active project in the laboratory involves elucidating the role of PI3K isoforms in regulating cardiac electrophysiology. We reported that downregulation of cardiac p110α signaling due to drug inhibition or diabetic conditions causes changes in multiple ion currents that result in prolongation of the QT interval on the ECG. QT prolongation in humans can increase the risk of fatal ventricular arrhythmias. We are now studying the mechanisms by which PI3K signaling regulates cardiac ion channel function.

Lab Members

Lisa Ballou PhD
Ya-Ping Jiang MD
Ray Chen
Shengnan Nancy Liu PhD
Stephanie Chapelliquen (Pharmacology PhD student)
Nithya Sivaram (MCB PhD student)
Jennifer DeLeon (MCB PhD student)
Anna Banach (MCB PhD student)

Selected Publications

 

Dr. Lin's publications may be found at the following NCBI link::

http://www.ncbi.nlm.nih.gov/sites/myncbi/richard.lin.1/bibliography/41160594/public/?sort=date&direction=descending

 

 

 

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