Publications, 2000-2004    

       T. Schindler, W. Bornmann, P. Pellicena, W.T. Miller, B. Clarkson, and J. Kuriyan (2000). Structural mechanism for the inhibition of Abelson tyrosine kinase by a small molecule inhibitor that is effective in the treatment of chronic myelogenous leukemia. Science 289, 1938-1942.  

M. Porter, T. Schindler, J. Kuriyan, and W.T. Miller (2000). Reciprocal regulation of Hck activity by phosphorylation of Tyr527 and Tyr416. J. Biol. Chem. 275, 2721-2726.     

    J.T. Nguyen, M. Porter, M. Amoui, W.T. Miller, R.N. Zuckermann, and W.A. Lim (2000). Improving SH3 domain ligand selectivity using a non-natural scaffold. Chemistry & Biology 7, 463-473.  

     M. Amoui and W.T. Miller (2000). The substrate specificity of the catalytic domain of Abl plays an important role in directing phosphorylation of the adaptor protein Crk. Cell Signal. 12, 637-643.  

     P.M. Chan, H.P. Nestler, and W.T. Miller (2000). Investigating the substrate specificity of the HER2/Neu tyrosine kinase using peptide libraries. Cancer Lett. 160, 159-169.    

     M.P. Scott and W.T. Miller (2000). A peptide model system for processive phosphorylation by Src-family kinases. Biochemistry 39, 14531-14537.

     W.T. Miller (2001). Double trouble. Nature Struct. Biol. 8, 16-18.

     N. Yokoyama, N.C. Reich, and W.T. Miller (2001). Involvement of protein phosphatase 2A in the interleukin-3 stimulated Jak2/STAT5 signalling pathway. J. Interferon Cytokine Research 21, 369-378.

    P. Pellicena and W.T. Miller (2001). Processive phosphorylation of p130Cas by Src is dependent on SH3-polyproline interactions. J. Biol. Chem 276, 28190-28196.

    N. Yokoyama and W.T. Miller (2001). Protein phosphatase 2A interacts with the Src kinase substrate p130Cas. Oncogene 20, 6057-6065.

     V. Boonyaratanakornkit, M.P. Scott, V. Ribon, L. Sherman, S.A. Anderson, J.L. Maller, W.T. Miller, and D.P. Edwards (2001). Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases.Molecular Cell 8, 269-280.

     M. Amoui, B.P. Craddock, and W.T. Miller (2001). Differential phosphorylation of IRS-1 by insulin and insulin-like growth factor 1 receptors in Chinese hamster ovary cells. J. Endocrinology 171, 153-162.

     K. Zou, W.T. Miller, R.S. Givens, and H. Bayley (2001). Caged thiophosphotyrosine peptides. Angew. Chem. Int. Ed. 40, 3049-3051.

    N. Yokoyama and W.T. Miller (2001). Inhibition of Src by direct interaction with protein phosphatase 2A. FEBS Letters 505, 460-464.

     S. Favelyukis, J.H. Till, S.R. Hubbard, and W.T. Miller (2001). Structure and autoregulation of the insulin-like growth factor 1 receptor kinase. Nature Structural Biol. 8, 1058-1063.

    P. Pellicena and W.T. Miller (2002). Coupling kinase activation to substrate recognition in Src-family tyrosine kinases. Front. Biosci. 7, 256-267.

    B. Nagar, W. Bornmann, P. Pellicena, T. Schindler, D. Veach, W.T. Miller, B. Clarkson, and J. Kuriyan (2002). Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and Imatinib (STI-571). Cancer Research 62, 4236-4243.

     M.P. Scott, F. Zappacosta, E.Y. Kim, R.S. Annan, and W.T. Miller (2002). Identification of novel SH3 domain ligands for the Src family kinase Hck: WASP. WIP, and ELMO1. J. Biol. Chem 277, 28238-28246.

     H. Qiu and W.T. Miller (2002). Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition. J. Biol. Chem 277, 34634-34641.

     W.T. Miller (2003). Determinants of substrate specificity in nonreceptor tyrosine kinases. Accounts of Chemical Research, 36, 393-400.

    N. Yokoyama, N.C. Reich, and W.T. Miller (2003). Determinants for the interaction between Janus kinase 2 and protein phosphatase 2A. Arch Biochem Biophys 417, 87-95.

    N. von Bubnoff, D.R. Veach, W.T. Miller, W. Li, . Sanger, C. Peschel, W.G. Bornmann, B. Clarkson, and J. Duyster (2003). Inhibition of wild-type and mutant Bcr-Abl by pyrimido-pyrimidine type small molecule kinase inhibitors. Cancer Research,63, 6395-6404.

    G.S. Goldberg, D.B. Alexander, P. Pellicena, Z.-Y. Zhang, H. Tsuda, and W.T. Miller (2003). Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells. J. Biol. Chem 278, 46533-46540.

    N. Yokoyama and W.T. Miller (2003). Biochemical properties of the Cdc42-associated tyrosine kinase ACK1: substrate specificity, autophosphorylation, and interaction with Hck. J. Biol. Chem 278, 47713-47723.

     H. Qiu and W.T. Miller (2004). Role of the Brk SH3 domain in substrate recognition. Oncogene 23, 2216-2223.

    Alexander, D.B., Ichikawa, I., Bechberger, J.F., Valiunas, V., Ohki, M., Naus, C.C.G., Kunimoto, T., Tsuda, H., W., Miller, W.T., and Goldberg, G.S (2004). Normal cells control the growth of neighboring transformed cells independent of gap junctional communication and Src activity. Cancer Research 64, 1347-1358.

     W. Li, S. Favelyukis, J. Yang, Y. Zeng, J. Yu, A. Gangjee, and W.T. Miller (2004). Inhibition of insulin-like growth factor I receptor autophosphorylation by novel 6-5 ring-fused compounds. Biochem. Pharm 68, 145-154.


Goldberg et al., JBC 278: 46533 (2003)