Faculty    |   Research Faculty    |   Joint Appointments    |   Adjunct Appointments

Kulandaiappan Varadaraj
Research Associate Professor

Ph.D. Madurai-Kamaraj (India), 1991

Basic Science Tower, T-6, Room 165
Stony Brook University
Stony Brook, NY, 11794-8661

Phone: (631) 444-7551
Fax: (631) 444-3432

Varadaraj CV


Our research focuses on the physiology and pharmacology of mammalian lens membrane transporters, with specific emphasis on aquaporins, glucose transporters, and Vitamin C transporters and their relation to lens cataract and transparency.

Selected Publications

Kumari S.S, Varadaraj K, Aquaporin 0 plays a pivotal role in refractive index gradient development in mammalian eye lens to prevent spherical aberration.Biochem Biophys Res Commun. 2014 Oct 3;452(4):986-991.

S Sindhu Kumari, N. Gupta, A. Shiels, P.G FitzGerald, A.G Menon, R.T.Mathias, K. Varadaraj,Role of Aquaporin 0 in lens biomechanics.Biochemical and Biophysical Research Communications(2015), doi: 10.1016/j.bbrc.2015.04.138.

Sindhu Kumari, S., Varadaraj, K. 2014. Intact and N- or C-terminal end truncated AQP0 function as open water channels and cell-to-cell adhesion proteins: End truncation could be a prelude for adjusting the refractive index of the lens to prevent spherical aberration.Biochim. Biophys. Acta, 1840: 2862-2877.

Kumari, S. S., Varadaraj, K. 2013. Aquaporin 5 knockout mouse lens develops hyperglycemic cataract. Biochem. Biophys. Res. Commun., 441: 333-338.

Yang, Y., Yang, H., Wang, Z., Varadaraj, K., Kumari, S. S., Mergler, S., Okada, Y., Saika, S., Kingsley, P. J., Marnett, L.J., Reinach, P. S. 2013. Cannabinoid receptor 1 suppresses transient receptor potential vanilloid 1-induced inflammatory responses to corneal injury. Cell Signal, 25: 501-511.

Kumari, S.S., Gandhi, J., Mustehsan, M.H., Eren, S., Varadaraj, K. 2013. Functional characterization of an AQP0 missense mutation, R33C, that causes dominant congenital lens cataract, reveals impaired cell-to-cell adhesion. Exp. Eye Res., 116: 371-385.

Gao, J., Wang, H., Sun, X., Varadaraj, K., Li, L., White, T.W., Mathias, R.T. 2013. The effects of age on lens transport. Invest. Ophthalmol .Vis. Sci., 54: 7174-7187.

Kumari, S.S., Varadaraj, M., Yerramilli, V.S., Anil G. Menon, A.G., Varadaraj, K. 2012. Spatial expression of aquaporin 5 in mammalian cornea and lens, and regulation of Its localization by phosphokinase A. Mol. Vis., 18:957-967.

Kumari, S.S., Eswaramoorthy, S., Mathias, R.T., Varadaraj, K. 2011. Unique and analogous functions of aquaporin 0 for fiber cell architecture and ocular lens transparency. Biochim. Biophys. Acta.,1812:1089-1097.

Varadaraj, K., Kumari, S. S. and Mathias, R. T. 2010. Transgenic Expression of AQP1 in the AQP0 knockout Mouse: Impact on Lens Transparency. Exp. Eye Res. 91:393-404.

Kumari, S. S. and Varadaraj, K. 2009. Intact AQP0 performs cell-to-cell adhesion. Biochem. Biophys. Res. Commun., 390:1034-1039.

Wang, H., Gao, J., Sun, X., Martinez-Wittinghan, F. J., Li, L., Varadaraj, K., Farrell, M., Reddy, V. N., White, T. W. and Mathias, R. T. 2009. The effects of GPX-1 knockout on membrane transport and intracellular homeostasis in the lens. J. Membr. Biol. 227:25-37.

Varadaraj, K., Kumari, S.S., Patil, R., Wax, M.B. and Mathias, R.T. 2008. Functional characterization of a human aquaporin 0 mutation that leads to a congenital dominant lens cataract. Exp. Eye Res., 87: 9-21.

Varadaraj, K., Kumari, S.S. and Mathias, R.T. 2007. Functional expression of aquaporins in embryonic, postnatal, and adult mouse lenses. Dev. Dyn., 236:1319-1328.

Varadaraj, K., Kumari, S.S. and Mathias, R.T. 2005. Regulation of aquaporin water permeability in the lens. Invest. Opthalmol. Vis. Sci., 46:1393-1402.

Shiels, A., Bassnett, S. Varadaraj, K., Mathias, R.T., Al-Ghoul, K., Kuszak, J., Donoviel, D., Lillenberg, S., Friedrich, G., and Zambrowicz, B. 2001. Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice. Physiol. Genomics 7:179-186.

Kumari, S. S., Varadaraj, K.,Valiunas, V., and Brink, P.R. 2001. Site-directed mutations in the transmembrane domain M3 of human connexin37 alter channel conductance and gating. Biochem. Biophys. Res. Commun., 280:440-447.

Kumari, S. S., Varadaraj, K.,Valiunas, V., Ramanan, S. V., Christensen, E. A., Beyer, E.C., and Brink, P.R. 2000. Functional expression and biophysical properties of polymorphic variants of the human gap junction protein Connexin 37. Biochem. Biophys. Res. Commun., 274:216-224.

Varadaraj, K., Kushmerick, C., Baldo, G.J., Shiels, A., Bassnett, S. and Mathias, R.T. 1999. Role of MIP in lens fiber cell membrane transport. J. Membrane Biol., 170:191-203.

Ramanan, S.V., Brink, P.R., Varadaraj, K., Schirrmacher, K. and Banach, K. 1998. A three-state model for connexin37 gating kinetics. Biophys. J. , 76:2520-2529.

Kushmerick, C., Varadaraj, K. and Mathias, R.T. 1998. Effect of lens Major Intrinsic Protein on glycerol permeability and metabolism. J. Membrane Biol., 161:9-19.

Varadaraj, K., Kumari, S. S. and Skinner, D. M.1997. Molecular characterization of four members of the a-tubulin gene family of the Bermuda land crab Gecarcinus lateralis. J. Exp. Zool.,278:63-77.

Varadaraj, K., Kumari, S. S. and Skinner, D. M. 1996. Actin-encoding cDNAs and gene expression during the intermolt cycle of the Bermuda land crab Gecarcinus lateralis. Gene, 171:177-184.

Varadaraj, K. and Skinner, D. M., 1994. Denaturants or cosolvents improve the specificity of PCR amplification of a G+C-rich DNA using genetically engineered DNA polymerases. Gene, 140:1-5.

Varadaraj, K., Kumari, S. S. and Pandian, T. J., 1994. Comparison of conditions for hormonal sex reversal of Mozambique tilapias. Prog. Fish-Cult., 56:81-90.

Varadaraj, K. and Skinner, D. M., 1994. Cytoplasmic localization of transcripts of a complex G+C-rich crab satellite DNA. Chromosoma, 103: 423-431.

Varadaraj, K. 1993. Production of viable haploid Oreochromis mossambicus gynogens using UV-irradiated sperms. J. Exp. Zool., 267:460-467.

Varadaraj, K and Pandian, T. J. 1991. Effect of solubilizing 17 a-ethynyltestosterone in three solvents on sex reversal ratio of Mozambique tilapia. Prog. Fish-Cult., 53:67-71.

Varadaraj, K., 1990. Dominant red colour morphology used to detect paternal contamination in batches of Oreochromis mossambicus (Peters) gynogens. Aquacult. Fish. Manag., 21:163-172.

Varadaraj, K. 1990. Production of monosex male Oreochromis mossambicus (Peters) by administering 19-norethisterone acetate. Aquacult. Fish. Manag., 21:133-135.

Pandian, T. J.and Varadaraj, K., 1990. Development of monosex female Oreochromis mossambicus broodstock by integrating gynogenetic technique with endocrine sex reversal. J. Exp. Zool., 255:88-96.

Varadaraj, K. and Pandian, T. J., 1990. Production of all-female sterile-triploid Oreochromis mossambicus. Aquaculture, 84:117-123.

Varadaraj, K., 1990. Production of diploid Oreochromis mossambicus gynogens using heterologous sperm of Cyprinus carpio. Indian J. Exp. Biol., 28:701-705.

Varadaraj, K, and Pandian, T. J., 1989. Induction of allotriploids in the hybrids of Oreochromis mossambicus female X red tilapia male. Proc. Indian Acad. Sci. (Anim. Sci.), 98:351-358.

Varadaraj, K. and Pandian, T. J., 1989. First report on production of supermale tilapia by integrating endocrine sex reversal with gynogenetic techniques. Curr. Sci., 58: 434-441.

Varadaraj, K., 1989. Feminization of Oreochromis mossambicus by the administration of diethylstilbestrol. Aquaculture, 80:337-341.

Varadaraj, K. and Pandian, T. J., 1988. Induction of triploids in Oreochromis mossambicus by thermal, hydrostatic pressure and chemical shock. Proc. Aquacult. Inter. Congress, Vancouver, Canada, pp. 531-535.

Varadaraj, K. and Pandian, T. J., 1987. Masculinization of Oreochromis mossambicus by administration of 17α-methyl-5-androsten-3β-17β-diol through rearing water. Curr. Sci., 56:412-413.



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